中西医结合四联疗法治疗肝经郁热型大面积带状疱疹40例

Clinical effect of integrated traditional Chinese and Western medicine therapy combined with quadruple therapy in treatment of extensive herpes zoster with stagnated heat of the liver meridians:An analysis of 40 cases

目的:观察中西医结合四联疗法(口服龙胆泻肝汤、患部散刺放血、穴位注射并配合静脉滴注阿昔洛韦)治疗肝经郁热型大面积带状疱疹的临床疗效。方法:将80例肝经郁热型大面积带状疱疹患者随机分成2组,每组各40例。治疗组采用中西医结合四联疗法治疗,对照组采用西医常规抗病毒方案(阿昔洛韦静脉滴注、双氯芬酸钠缓释片口服)治疗;疗程均为10 d。比较2组治疗前后视觉模拟量表(VAS)评分、临床症状评分,评定综合疗效,治疗结束后2个月随访统计后遗神经痛的发生率。结果:总有效率治疗组为92.50%(37/40),对照组为77.50%(32/40),组间比较,差异有统计学意义(P<0.05)。治疗后2组VAS评分、临床症状评分均较治疗前降低(P<0.01),且治疗组低于对照组(P<0.01)。后遗神经痛发生率治疗组为12.50%(5/40),对照组为32.50%(13/40),差异有统计学意义(P<0.01)。结论:中西医结合四联疗法治疗肝经郁热型大面积带状疱疹效果优于西医常规治疗。

Objective:To investigate the clinical effect of integrated traditional Chinese and Western medicine therapy combined with quadruple therapy(oral administration of Longdan Xiegan decoction,scattered needling and exsanguination at the lesion,acupoint injection,and intravenous drip of acyclovir)in the treatment of extensive herpes zoster with stagnated heat of the liver meridians.Methods:A total of 80 patients with extensive herpes zoster with stagnated heat of the liver meridians were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the treatment group were given integrated traditional Chinese and Western medicine therapy combined with quadruple therapy,and those in the control group were given conventional Western medicine antiviral therapy(intravenous drip of acyclovir and oral administration of diclofenac sodium sustained-release tablets);the course of treatment was 10 days for both groups.The two groups were compared in terms of Visual Analogue Scale(VAS)score and clinical symptom score before and after treatment,overall response was evaluated,and follow-up was performed at 2 months after the end of treat-ment to observe the incidence rate of postherpetic neuralgia.Results:There was a significant difference in overall response rate between the treatment group and the control group[92.50%(37/40)vs 77.50%(32/40),P<0.05].After treatment,both groups had significant reductions in VAS score and clinical symptom score(P<0.01),and the treatment group had significantly lower scores than the control group(P<0.01).There was a significant difference in the incidence rate of postherpetic neuralgia between the treatment group and the control group[12.50%(5/40)vs 32.50%(13/40),P<0.01].Conclusion:Integrated traditional Chinese and Western medicine therapy combined with quadruple therapy has a better clinical effect than conventional Western medicine treatment in the treatment of extensive herpes zoster with stagnated heat of the liver meridians.