代谢综合征与阿尔茨海默病的相关性及机制研究进展

Research Progress of Correlation and Underlying Mechanisms between Metabolic Syndrome and Alzheimer's Disease

近期研究发现代谢综合征(MetS)患者有认知功能下降甚至向痴呆进展的趋势,而阿尔茨海默病(AD)是痴呆最重要的分型。本文回顾总结既往研究中MetS导致的认知功能障碍与AD发病的相关性,指出有较多证据支持MetS作为整体及其组分中的高血压、高血糖是AD的危险因素,而胰岛素抵抗、神经慢性炎症、脂肪因子紊乱等在发病过程中起到重要作用,因尚缺乏可有效延缓或逆转AD病理进展的治疗方案,期待以相对可治MetS为干预靶标,为早期防治AD综合策略的制订提供科学证据。

Recent studies have identified a trend toward cognitive decline and even progression to dementia in patients with metabolic syndrome(MetS),and Alzheimer's disease(AD)is the most important subtype of dementia.In reviewing the correlation between cognitive impairment due to MetS and development of AD in previous studies,this paper highlights the growing body of data that supports MetS as a whole as well as its components of hypertension and hyperglycemia as risk factors for AD,whereas insulin resistance,neurologic chronic inflammation,and adipokine disorders play important roles in the pathogenesis.Since there are now no viable treatment alternatives available to stop or reverse the degenerative progression of AD,it is expected to provide scientific evidence for a comprehensive strategy for early prevention and treatment of AD by targeting relatively curable MetS for intervention.