ApoB/ApoA1与糖尿病视网膜病变继发玻璃体积血的相关性研究

Study of the correlation between ApoB/ApoA1 and vitreous hemorrhage secondary to diabetic retinopathy

目的探讨ApoB/ApoA1与糖尿病视网膜病变(DR)继发玻璃体积血(VH)的相关性。方法收集2021年8月至2022年12月的187例DR患者,分为VH组(96例)及非VH组(91例),对比两组患者临床基本资料,并采用Logistic回归分析DR继发VH的危险因素。结果两组的年龄、性别、病程、BMI、高血压病史、吸烟、饮酒之间差异无统计学意义(P>0.05)。VH组空腹血糖(FPG)、糖化血红蛋白A1c(HbA1c)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、ApoB/ApoA1及血清纤维蛋白原(FIB)高于非VH组(P均<0.05),而TG、APTT、PT、TT在两组间差异无统计学意义(P均>0.05)。HbA1c[OR=1.438(1.179~1.864)]、ApoB/ApoA1[OR=25.274(5.699~112.092)]及FIB[OR=1.471(1.022~2.118)]是VH发生的影响因素(P均<0.05)。结论HbA1c、ApoB/ApoA1及FIB与VH密切相关,监测血糖、血脂、凝血功能,及时干预,可以使DR病程进展得到延缓,降低VH的发生率。

Objective To investigate the correlation between ApoB/ApoA1 and vitreous hemorrhage(VH)secondary to diabetic retinopathy(DR).Methods 187 patients with DR from August 2021 to December 2022 were recruited and divided into VH(n=96)and non-VH groups(n=91).Baseline data were compared between two groups.The risk factors of VH secondary to DR were analyzed by Logistic regression analysis.Results There were no significant differences in age,gender,course of disease,body mass index(BMI),history of hypertension,smoking and drinking between two groups(all P>0.05).In the VH group,fasting plasma glucose(FPG),glycosylated hemoglobin A1(c HbA1c),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),lowdensity lipoprotein cholesterol(LDL-C),ApoB/ApoA1 and FIBrinogen(FIB)were significantly higher compared with those in the non-VH group,and the differences were statistically significant(all P<0.05),while there were no significant differences in TG,APTT,PT and TT between two groups(all P>0.05).HbA1c(OR=1.438(1.179-1.864)),ApoB/ApoA1(OR=25.274(5.699~112.092))and FIB(OR=1.471(1.022~2.118))were the risk factors for VH(all P<0.05).Conclusions HbA1c,ApoB/ApoA1 and FIB are closely related to VH.Monitoring blood glucose,lipid and coagulation and timely intervention can delay the progression of DR and reduce the incidence of VH.