热疗对肿瘤微环境中肿瘤相关成纤维细胞作用的研究进展

Research progress on the effect of hyperthermia on cancer-associated fibroblasts in tumor microenvironment

肿瘤微环境具有免疫抑制特性,其作用机制是诱导肿瘤细胞的免疫逃逸,它与肿瘤细胞之间的相互作用是影响肿瘤发生发展的重要因素。肿瘤相关成纤维细胞是肿瘤微环境的一个重要组成部分,其主要功能是与肿瘤细胞发生直接或间接的相互作用,并产生各种细胞因子,从而对肿瘤免疫微环境起到调节作用。肿瘤热疗作为抗肿瘤治疗的一种手段,随着对肿瘤热疗和肿瘤微环境的研究不断深入,大量研究发现热疗对肿瘤微环境中的肿瘤相关成纤维细胞具有多种调节功能。本文结合国内外最新研究进展,阐述热疗对肿瘤微环境中肿瘤相关成纤维细胞及其相关细胞和因子的影响,为肿瘤热疗结合免疫或靶向治疗的临床应用提供新途径。

Tumor microenvironment possesses immunosuppression characteristics via the mechanism of inducing tumor cell immune escape.The interaction between tumor cells and tumor microenvironment is an important factor affecting tumor genesis and development.As an important part of tumor microenvironment,cancer-associated fibroblasts interact directly or indirectly with tumor cells and produce various cytokines to regulate tumor immune microenvironment.In recent years,hyperthermia has become an auxiliary means of anti-tumor therapy.With the development of research on tumor hyperthermia and tumor microenvironment,a large number of studies have found that hyperthermia can regulate cancer-associated fibroblasts in tumor microenvironment.In this article,recent research progresses of the effects of hyperthermia on cancer-associated fibroblasts and related cells and cytokines in tumor microenvironment were reviewed,providing a new way for clinical application of hyperthermia combined with immune or targetedtherapy.