高脂血症性胰腺炎病情严重程度的危险因素分析

Analysis of Risk Factors for the Severity of Hyperlipidemic Pancreatitis

目的:探讨高脂血症性急性胰腺炎(HLAP)病情严重程度的危险因素。方法:选取2020年1月—2023年1月南通市通州区人民医院收治的HLAP患者144例作为研究对象。根据入院时的改良Marshall评分分为轻中度组(76例,改良Marshall评分<2分)和重度组(72例,改良Marshall评分≥2分)。对两组患者进行单因素分析后再进行多因素Logistic回归分析,探讨影响HLAP病情严重程度的独立危险因素,比较两组患者HLAP分型、局部并发症发生率。结果:体重指数(BMI)、空腹血糖、血清甘油三酯水平及天门冬氨酸氨基转移酶水平是HLAP的独立危险因素(P<0.05);重度组坏死型HLAP发生率、局部并发症发生率高于轻中度组,差异有统计学意义(P<0.05)。结论:血清甘油三酯水平、BMI、天门冬氨酸氨基转移酶、空腹血糖是影响HLAP病情严重程度的独立危险因素,在临床上可以针对上述高危因素人群进行早筛查、早诊断,降低HLAP的发生率,改善临床结局。

Objective:To investigate the risk factors for the severity of hyperlipidemic acute pancreatitis(HLAP).Methods:A total of one hundred and forty-four patients with HLAP admitted to Tongzhou District People's Hospital of Nantong City from January 2020 to January 2023 were selected as the study objects.According to the improved Marshall score at admission,the patients were divided into mild to moderate group(76 cases,improved Marshall score<2 points)and severe group(72 cases,improved Marshall score≥2 points).Multivariate logistic regression analysis was performed after univariate analysis.The independent risk factors affecting the severity of HLAP was explored,and the HLAP type and local complication rate between the two groups were compared.Results:Body mass index(BMI),fasting blood glucose,serum triglyceride level and aspartate aminotransferase level were independent risk factors for HLAP(P<0.05);The incidence of necrotic HLAP and local complications in severe group was higher than that in mild to moderate group,and the difference was statistically significant(P<0.05).Conclusion:Serum triglyceride level,BMI,aspartate aminotransferase and fasting blood glucose are independent risk factors that affect the severity of HLAP.Early screening and diagnosis can be performed in clinical practice to reduce the incidence of HLAP and improve clinical outcomes.