非肌层浸润性膀胱癌的分子亚型及其临床价值

Molecular Subtypes of Non-muscular Invasive Bladder Cancer and Their Clinical Value

高通量测序分析提高了临床对膀胱癌生物学的理解,该文通过对相关文献进行检索并综述。非肌层浸润性膀胱癌分子亚型包括Ⅰ类、Ⅱ类和Ⅲ类,其中Ⅰ类具有管腔样特征,预后良好,特征是早期细胞周期素D1和成纤维细胞生长因子受体3突变的表达升高;Ⅱ类具有管腔型特征,特征是晚期细胞周期调节因子和与上皮-间充质转化和表皮生长因子受体2相关的转录因子表达升高;Ⅲ类具有基底样特征,预后较差,总生存期较短,特征是肿瘤向基底型转变,伴成纤维细胞生长因子受体3突变。分子亚型可以表征膀胱癌的不同进展途径,还可用来预测对治疗的反应。该文旨在总结非肌层浸润性膀胱癌分子亚型及其临床特征。

High-throughput sequencing analysis has improved the clinical understanding of the biology of bladder cancer.This article searched and reviewed the relevant literature.The molecular subtypes of non-muscular invasive bladder cancer include class Ⅰ,class Ⅱ and class Ⅲ.Among them,class Ⅰ has lumen-like features and a good prognosis,characterized by increased expression of early cyclin PROD1 and fibroblast growth factor receptor3 mutations.Class Ⅱ has a lumen type characteristic,characterized by increased expression of late cell cycle regulators and transcription factors associated with epithelial-mesenchymal transformation and epidermal growth factor receptor 2.Class Ⅲ has basal-like features,poor prognosis and short overall survival,characterized by tumor transformation to basal-type with fibroblast growth factor receptor 3 mutation.Molecular subtypes can characterize different pathways of bladder cancer progression and can also be used to predict response to treatment.This article aimed to summarize the molecular subtypes and clinical features of non-muscular invasive bladder cancer.