摘要
目的观察金鉴胃爱汤及体质调节治疗脾胃虚弱型胃癌前病变的临床疗效。方法将110例患者采用随机数字表法按1∶1比例分为治疗组和对照组各55例,2组均予胃黏膜保护剂瑞巴派特口服3月,治疗组同时给予金鉴胃爱汤口服3个月,配合体质调节半年。结果治疗组胃黏膜改善有效率显著高于对照组(P<0.01);治疗组的组织病理学评分优于对照组(P<0.01),治疗组对低级别上皮内瘤变(LGIN)的病理疗效优于治疗前(P<0.01);治疗后,治疗组体质转化分优于对照组(P<0.01);治疗组症状积分优于对照组(P<0.05);中医症状缓解总有效率治疗组优于对照组(P<0.01)。结论金鉴胃爱汤及体质调节治疗脾胃虚弱型胃癌前病变有显著疗效,安全性好。
Objective To observe the clinical effect of Jinjian Weiai decoction and constitution regulation in the treatment of precancerous lesions of gastric cancer of deficiency of spleen and stomach type.Methods A total of 110 patients were included by random number table method in a 1∶1 ratio and divided into the treatment group and the control group,with 55 patients in each group.Both groups were given oral administration of gastric mucosa protective agent Rebabapide for 3 months,and the treatment group was given oral administration of Jinjian Weiai decoction for 3 months,combined with physical regulation for half a year.Results The effective rate of gastric mucosa improvement in the treatment group was significantly higher than that in the control group(P<0.01).The pathological effect of the treatment group on CAG and IM was better than that of the control group(P<0.01),and the pathological effect of the treatment group on LGIN was better than that before treatment(P<0.01).The score of physical transformation after treatment was better in the treatment group than in the control group(P<0.01).Symptom score after treatment was better in treatment group than in control group(P<0.05).The total effective rate of symptom relief in the treatment group was better than that in the control group(P<0.01).Conclusion Jinjian Weiai decoction and constitution regulation have significant efficacy and safety in the treatment of precancerous lesions of stomach and spleen asthenia.
作者
李华东
唐伟
孙长代
马燕
伍芳
张玉佩
LI Huadong;TANG Wei;SUN Changdai;MA Yan;WU Fang;ZHANG Yupei(Department of Gastroenterology,Lu’an Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine,Anhui Province,Lu’an 237006,China;Graduate School,Anhui University of Chinese Medicine,Anhui Province,Hefei 230012,China)
出处
《光明中医》
2023年第17期3287-3290,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
安徽省中医药传承创新科研项目(No.2020zcyb24)
安徽中医药大学科研项目(No.LAZD002)。
关键词
胃脘痛
胃癌前病变
金鉴胃爱汤
体质
脾胃虚弱证
stomach pain
precancerous lesion of gastric cancer
Jinjian Weiai decoction
constitution
deficiency of spleen and stomach