壮督除痹丸治疗慢性非特异性腰痛临床研究

Clinical study of Zhuangdu Chubi pill in the treatment of chronic nonspecific low back pain

目的:观察壮督除痹丸治疗非特异性腰痛的临床疗效。方法:纳入2020年4月~2021年11月在本院康复医学科的非特异性腰痛患者200例为研究对象,随机分为壮督除痹丸组(简称壮督组)、独活寄生丸组(后简称独活组)各100例。两组均在基础治疗上,分别采用壮督除痹丸和独活寄生丸治疗,1个月为1疗程。观察VAS评分、ODI指数、实验室检查[血清P物质(SP)、白细胞介素-6(IL-6)]以及临床疗效。结果:在VAS与ODI指数结果方面,治疗前独活组和壮督组在疼痛指标VAS评分与运动功能ODI指数的组间比较,差异均无统计学意义(P>0.05)。治疗1个月后,独活组和壮督组上述两指标均优于治疗前,差异有统计学意义(P<0.05)。而组间比较,壮督组在VAS与ODI指数评分优于独活组,差异有统计学意义(P<0.05);而治疗3个月后,壮督组在VAS与ODI指数评分优于独活组,差异有统计学意义(P<0.05)。在实验室指标方面,治疗前独活组和壮督组在SP和IL-6的组间比较,差异均无统计学意义(P>0.05)。治疗1个月后,独活组和壮督组在上述两指标均优于治疗前,差异有统计学意义(P<0.05)。而组间比较,壮督组在IL-6优于独活组,而在SP两组无差异(P>0.05)。而治疗3个月后,壮督组在两项实验室检查均优于独活组,差异有统计学意义(P<0.05)。在临床疗效方面,壮督组在治疗后1个月、3个月和6个月的显效率为57%、56%、47%,3个时间节点均优于独活组,差异有统计学意义(P<0.05)。结论:壮督除痹丸以督脉为切入点,治疗非特异性腰痛疗效确切,可以有效缓解疼痛,改善功能障碍,提高疗效,值得继续研究。

Objective:To observe the clinical efficacy of Zhuangdu Chubi pill in the treatment of nonspecific low back pain.Methods:200patients with non-specific low back pain in the Department of rehabilitation medicine of our hospital from April 2020to September 2021were randomly divided into Zhuangdu Chubi pill group(hereinafter referred to as Zhuang Du group)and Duhuo Jisheng pill group(hereinafter referred to as Duhuo group).On the basis of basic treatment,the two groups were treated with Zhuangdu Chubi pill and Duhuo Jisheng pill respectively.One month was one course of treatment.The VAS score,ODI index,laboratory examination[serum substance P(SP),interleukin-6(IL-6)]and clinical efficacy were observed.Results:in terms of VAS and ODI index,there was no significant difference between Duhuo group and Zhuangdu group in VAS scores and ODI scores of motor function before treatment(P>0.05).After one month of treatment,the above two indexes in Duhuo group and Zhuangdu group were better than those before treatment,and the difference was statistically significant(P<0.05).The VAS and ODI scores of Zhuangdu group were better than those in the Duhuo group(P<0.05);After 3months of treatment,the VAS and ODI index scores in the Zhuangdu group were better than those in the Duhuo group(P<0.05).In terms of laboratory indexes,there was no significant difference in SP and IL-6between Duhuo group and Zhuangdu group before treatment(P>0.05).After one month of treatment,the above two indexes in Duhuo group and Zhuangdu group were better than those before treatment,and the difference was statistically significant(P<0.05).The IL-6of Zhuangdu group was better than that of Duhuo group,but there was no difference in SP between the two groups(P>0.05).After 3months of treatment,Zhuangdu group was better than Duhuo group in two laboratory tests,and the difference was statistically significant(P<0.05).In terms of clinical efficacy,the effective rates of Zhuangdu group at 1month,3months and 6months after treatment were 57%,56%and 47%,which were better than that of Duhuo group at three time points(P<0.05).Conclusion:Zhuangdu Chubi pill h is effective in the treatment of nonspecific low back pain,which can effectively relieve pain,improve dysfunction and curative effect,which is worthy of further research.