腹腔感染致脓毒症患者外周血Cor、PCT、WBC水平变化及其临床意义

Changes of Cor,PCT and WBC Levels in Peripheral Blood of Patients with Sepsis Caused by Abdominal Infection and Their Clinical Significance

目的 探讨腹腔感染致脓毒症患者外周血皮质醇(Cor)、降钙素原(PCT)、白细胞计数(WBC)水平变化及其临床意义。方法 82例腹腔感染致脓毒症患者分为轻中度脓毒症组和重度脓毒症组,比较两组的外周血Cor、 PCT、 WBC水平,探讨外周血Cor、 PCT、 WBC水平与病情进展的相关性。结果 重度脓毒症组的外周血Cor、 PCT、 WBC水平均高于轻中度脓毒症组(P<0.05)。Logistic回归分析显示,腹腔感染致脓毒症患者的外周血Cor、 PCT、 WBC水平与其病情进展存在相关性(OR>1,P<0.05);ROC曲线显示,Cor、 PCT、 WBC联合检测判断疾病进展的特异度、敏感度均高于单一指标检测。结论 腹腔感染致脓毒症患者的外周血Cor、 PCT、 WBC水平变化与其病情进展关系密切,联合检测可及时判断病情进展情况。

Objective To explore the changes of cortisol(Cor),procalcitonin(PCT)and white blood cell count(WBC)levels in peripheral blood of patients with sepsis caused by abdominal infection and their clinical significance.Methods 82 patients with sepsis caused by abdominal infection were divided into mild to moderate sepsis group and severe sepsis group.The levels of Cor,PCT and WBC in peripheral blood were compared between the two groups,and the correlations between the levels of Cor,PCT and WBC in peripheral blood and the progression of the disease were discussed.Results The levels of Cor,PCT and WBC in peripheral blood of severe sepsis group were higher than those of mild to moderate sepsis group(P<0.05).Logistic regression analysis showed that the levels of Cor,PCT and WBC in peripheral blood of patients with sepsis caused by abdominal infection were correlated with the progression of the disease(OR>1,P<0.05).ROC curve showed that the specificity and sensitivity of combined detection of Cor,PCT and WBC in judging disease progression were higher than those of single index detection.Conclusions The changes of Cor,PCT and WBC levels in peripheral blood of patients with sepsis caused by abdominal infection are closely related to the progression of the disease.Combined detection can timely judge the progression of the disease.