脂蛋白相关磷脂酶A2、D-二聚体联合检测诊断缺血性脑卒中的临床应用价值分析

Analysis on the Clinical Application Value of Combined Detection of Lipoprotein-Associated Phospholipase A2 and D-Dimer in the Diagnosis of Ischemic Stroke

目的 分析脂蛋白相关磷脂酶A2 (Lp-PLA2)、 D-二聚体(D-D)联合检测诊断缺血性脑卒中的临床应用价值。方法 选取72例缺血性脑卒中患者作为观察组,72例健康者作为对照组,比较两组的Lp-PLA2、 D-D水平;绘制ROC曲线分析Lp-PLA2、 D-D及二者联合对缺血性脑卒中的诊断效能。结果 观察组的Lp-PLA2、 D-D水平均高于对照组(P<0.05)。ROC曲线显示,Lp-PLA2、 D-D及二者联合诊断缺血性脑卒中的曲线下面积分别为0.824、 0.795、 0.939,联合检测的诊断效能最高。结论 Lp-PLA2、 D-D联合检测可提高缺血性脑卒中的诊断灵敏度、特异性,应用价值较高。

Objective To analyze the clinical application value of combined detection of lipoprotein-associated phospholipase A2(Lp-PLA2)and D-Dimer(D-D)in the diagnosis of ischemic stroke.Methods 72 patients with ischemic stroke were selected as the observation group,72 healthy people were selected as the control group,and the levels of Lp-PLA2 and D-D were compared between the two groups.ROC curve was drawn to analyze the diagnostic efficiency of Lp-PLA2,D-D and their combination for ischemic stroke.Results The levels of Lp-PLA2 and D-D in the observation group were higher than those in the control group(P<0.05).ROC curve showed that the area under the curve of Lp-PLA2,D-D and their combination in the diagnosis of ischemic stroke were 0.824,0.795 and 0.939,respectively,and the diagnostic efficiency of combined detection was the highest.Conclusions The combined detection of Lp-PLA2 and D-D can improve the diagnostic sensitivity and specificity for ischemic stroke,and has high application value.