甲强龙联合阿奇霉素治疗病毒性肺炎的临床效果及安全性分析

Analysis on the Clinical Effect and Safety of Methylprednisolone Combined with Azithromycin in the Treatment of Viral Pneumonia

目的 分析低剂量甲强龙联合阿奇霉素治疗病毒性肺炎的临床效果及安全性。方法 80例病毒性肺炎患者随机分为两组各40例。对照组给予基础治疗+阿奇霉素,观察组在对照组基础上给予低剂量甲强龙治疗。比较两组的治疗效果、血清炎性因子(CRP、 PCT、 IL-6)水平以及不良反应。结果 观察组的治疗总有效率为95.00%,高于对照组的77.50%(P<0.05)。治疗后,观察组的CRP、 PCT及IL-6水平均低于对照组(P<0.05)。治疗期间,两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 低剂量甲强龙联合阿奇霉素治疗病毒性肺炎的效果较好,可有效改善患者机体炎性状态,且安全性高。

Objective To analyze the clinical effect and safety of low-dose methylprednisolone combined with azithromycin in the treatment of viral pneumonia.Methods A total of 80 patients with viral pneumonia were randomly divided into two groups,with 40 cases in each group.The control group was treated with basic therapy+azithromycin,and the observation group was treated with low-dose methylprednisolone on the basis of the control group.The treatment effect,levels of serum inflammatory factors(CRP,PCT,IL-6)and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,higher than 77.50%in the control group(P<0.05).After treatment,the levels of CRP,PCT and IL-6 in the observation group were lower than those in the control group(P<0.05).During the treatment,no significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Low-dose methylprednisolone combined with azithromycin in the treatment of viral pneumonia has good effect,which can effectively improve the inflammatory state of patients,and has high safety.