羟氯喹联合泼尼松治疗IgA肾病患者的临床效果及对肾功能的影响

Clinical Effect of Hydroxychloroquine Combined with Prednisone in the Treatment of Patients with IgA Nephropathy and Its Impact on Renal Function

目的 探讨羟氯喹联合泼尼松治疗免疫球蛋白A肾病(IgAN)患者的临床效果及对肾功能的影响。方法 90例IgAN患者随机分为两组各45例。对照组采用泼尼松治疗,研究组采用羟氯喹联合泼尼松治疗。比较两组的临床疗效、肾功能指标及不良反应。结果 研究组的治疗总有效率为93.33%,高于对照组的77.78%(P<0.05)。治疗6个月后,研究组的24 h尿蛋白、血肌酐及尿素氮水平均低于对照组,肾小球滤过率高于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(11.11%vs.6.67%,P>0.05)。结论 羟氯喹联合泼尼松治疗IgAN患者的效果显著,可改善患者的肾功能,且安全性较高。

Objective To explore the clinical effect of hydroxychloroquine combined with prednisone in the treatment of patients with IgA nephropathy(IgAN)and its impact on renal function.Methods 90 patients with IgAN were randomly divided into two groups,with 45 cases in each group.The control group was treated with prednisone,and the study group was treated with hydroxychloroquine combined with prednisone.The clinical efficacy,renal function indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 93.33%,higher than 77.78%in the control group(P<0.05).After 6 months of treatment,the levels of 24 h urine protein,serum creatinine and urea nitrogen in the study group were lower than those in the control group,and the glomerular filtration rate was higher than that in the control group(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(11.11%vs.6.67%,P>0.05).Conclusions Hydroxychloroquine combined with prednisone in the treatment of patients with IgAN has significant effect and high safety,and can improve patients'renal function.