非酒精性脂肪肝发病相关影响因素研究——基于广西南宁某体检中心对象

Study on the Related Influencing Factors of Non-alcoholic Fatty Liver Disease (NAFLD):Based on the Object of a Physical Examination Center in Nanning,Guangxi

本研究旨在探讨非酒精性脂肪肝(Non-alcoholic Fatty Liver Disease, NAFLD)发病的影响因素,为降低该病发病概率,改善其预后采取的相关健康干预措施提供参考依据。本研究以广西南宁某体检中心常规体检者为研究对象,收集其健康体检相关指标[年龄、性别、身体质量指数(BMI)],血液生化指标[血谷丙转氨酶(ALT)、谷草转氨酶(AST)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)];通过调查问卷收集生活方式指标。以超声判断是否发生NAFLD,比较NAFLD患者和非NAFLD群体各指标,并通过逻辑回归分析NAFLD发生的影响因素。调查结果显示在577例研究对象中有184例被诊断为NAFLD,患病率为31.89%。多因素逻辑回归分析结果显示,超重、肥胖、TG高危水平以及以细粮为主的饮食方式是NAFLD发病的独立危险因素。超重、肥胖、TG高危水平以及以细粮为主的饮食方式是男性NAFLD发病的独立危险因素;年龄大于60岁、经常摄入豆类是男性NAFLD发病的保护性因素。超重、肥胖、TG水平边缘升高与TG高危水平是女性NAFLD发病的独立危险因素。综上,控制好BMI与TG水平有助于预防NAFLD发病,并且改变细粮为主的主食结构与增加豆类的摄入有助于预防男性NAFLD发病。

The purpose of this study was to investigate the influencing factors of Non-alcoholic Fatty Liver Disease(NAFLD),and to provide reference for reducing the incidence of the disease and improving its prognosis by taking relevant health interventions.In this study,the subjects of routine physical examination in a health management center in Nanning,Guangxi were selected as the research objects,and their health examination related indicators[age,gender,Body Mass Index(BMI),blood biochemical indicators[Alanine aminotransferase(ALT),Aspartate aminotransferase(AST),Fasting Plasma Glucose(FPG),Total Cholesterol(TC),Triglyceride(TG),High-Density Lipoprotein(HDL)and Low-Density Lipoprotein(LDL)were collected.Lifestyle indicators were collected through a questionnaire survey.Ultrasound was used to determine whether NAFLD occurred.The indicators of NAFLD patients and non-NAFLD groups were compared,and the influencing factors of NAFLD were analyzed by logistic regression.The survey results showed that among the 577 study subjects,184 were diagnosed with NAFLD,with a prevalence of 31.89%.Multivariate logistic regression analysis showed that being overweight,obesity,high-risk level of TG and fine grain-based diet were independent risk factors for NAFLD.Being overweight,obesity,high risk of TG and fine grain-based diet were independent risk factors for NAFLD in men.Being≥60 years old and regular intake of beans were protective factors for NAFLD in men.Being overweight,obesity,marginally elevated TG level,and high-risk TG level were independent risk factors for NAFLD in women.In summary,controlling BMI and TG levels is helpful to prevent the incidence of NAFLD,while changing the structure of staple food based on fine grains and increasing the intake of beans can help prevent the incidence of NAFLD in men.