摘要
目的 观察益气通腑推拿法治疗儿童便秘气虚型的临床疗效。方法 选取2020年1月至2021年12月余姚市妇幼保健院儿科收治的便秘气虚型患儿92例,采用随机数字表法分为对照组和治疗组,各46例。对照组予乳果糖口服液治疗,治疗组予益气通腑推拿法治疗。2组均连续治疗2周后统计临床疗效,比较治疗前后临床症状积分,肠道内菌群数量和血清肠神经递质[神经源性一氧化氮合酶(nNOS)、生长抑素(SS)、血管活性肠肽(VIP)]水平变化,并随访6个月后的复发率。结果 治疗组总有效率为93.48%(43/46),对照组为76.09%(35/46),2组比较,差异有统计学意义(P<0.05)。治疗前2组临床症状评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组临床症状评分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组双歧杆菌、乳酸杆菌、葡萄球菌、大肠杆菌数量比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组双歧杆菌、乳酸杆菌数量升高,葡萄球菌、大肠杆菌数量降低,与同组治疗前比较,差异有统计学意义(P<0.05),2组之间比较,差异无统计学意义(P<0.05)。治疗前2组血清肠神经递质nNOS、SS、VIP水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标水平均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。电话随访6个月,治疗组无复发,对照组复发率为11.43%(4/35),2组复发率比较,差异有统计学意义(P<0.05)。结论 益气通腑推拿法治疗儿童便秘气虚型可显著改善临床症状评分,降低血清肠神经递质指标水平,增加肠道有益菌数量,降低复发率,值得临床推广应用。
Objective To observe the therapeutic effect of Yiqi Tongfu Tuina method on constipation in chil⁃dren with qi deficiency syndrome.Methods From January 2020 to December 2021,92 cases of constipation in chil⁃dren with qi deficiency syndrome admitted to the pediatric department of Yuyao Maternal and Child Health Hospital were divided into a control group and a treatment group,with 46 cases in each group.The control group was treated with Lactulose oral liquid,and the treatment group was treated with Yiqi Tongfu Tuina method.After 2 weeks of con⁃tinuous treatment,the clinical efficacy of the two groups was counted,and the clinical symptom scores,the number of intestinal flora and the changes of serum intestinal neurotransmitters[Neurogenic nitric oxide synthase(nNOS),so⁃matostatin(SS),Vasoactive intestinal peptide(VIP)]levels were compared before and after treatment.The recur⁃rence rate was followed up for 6 months.Results The total effective rate of the treatment group was 93.48%(43/46),the control group was 76.09%(35/46),and the difference between the two groups was statistically sig⁃nificant(P<0.05).There was no statistically significant difference in clinical symptom scores between the two groups before treatment(P>0.05),indicating comparability.After treatment,the clinical symptom scores of both groups significantly decreased,and compared with the same group before treatment,the difference was statistically significant(P<0.05),and the decrease was more significant in the treatment group(P<0.05).There was no statis⁃tically significant difference in the levels of serum intestinal neurotransmitters nNOS,SS,and VIP between the two groups before treatment(P>0.05),indicating comparability.After treatment,the levels of the above indicators signif⁃icantly decreased,and compared with the same group before treatment,the difference was statistically significant(P<0.05),and the decrease was more significant in the treatment group(P<0.05).Telephone follow⁃up for 6 months showed no recurrence in the treatment group,while the recurrence rate in the control group was 11.43%(4/35).The difference in recurrence rates between the two groups was statistically significant(P<0.05).Conclu⁃sion Yiqi Tongfu Tuina therapy can significantly improve clinical symptom scores,reduce serum levels of intestinal neurotransmitter indicators,increase the number of beneficial bacteria in the intestine,and reduce recurrence rates of constipation in children with qi deficiency syndrome.It is worthy of clinical promotion and application.
作者
胡晔晴
黄璐
HU Yeqing;HUANG Lu(Department of Pediatrics,Yuyao Maternal and Child Health Hospital,Yuyao,Zhejiang,315400,China)
出处
《中医儿科杂志》
2023年第5期88-92,共5页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
便秘
儿童
气虚型
推拿
益气通腑法
临床观察
constipation
children
qi deficiency syndrome
tuina
Yiqi Tongfu method
clinical observation