钇90微球放射栓塞治疗肝脏恶性肿瘤研究的全球现状与发展趋势:一项文献计量学分析

The global status and development trends of radioembolization for liver cancer with yttrium-90:a bibliometric analysis

目的:通过文献计量学分析探讨钇90微球放射栓塞治疗肝脏恶性肿瘤研究的全球现状与发展趋势。方法:以Web of Science数据库中1991-2021年收录的钇90微球放射栓塞治疗肝脏恶性肿瘤相关文献为对象,应用VOS viewer软件对国家、机构、作者、期刊、关键词进行文献计量学分析,并绘制可视化的合作关系网络图谱。结果:根据检索策略和筛选标准,共989篇钇90微球放射栓塞治疗肝脏恶性肿瘤的相关文献纳入本研究,来自47个国家1055个机构4406名研究人员参与其中。该领域发表文献数量整体呈明显上升趋势,2021年达到峰值。美国在国家合作和发表文献数量上占据主导地位。在机构中,美国的西北大学发表文献数量最多,西班牙的纳瓦拉大学和美国的华盛顿大学次之。发表文献数量和总被引频次前3位的作者分别是Salem R、Lewandowski RJ和Mulcahy MF。Journal of Vascular and Interventional Radiology等期刊在推动该领域发展中发挥了重要作用。出现频次最高的10个关键词是放射栓塞、肝细胞癌、钇90、钇90微球、生存、癌症、肝转移、微球、选择性内放射治疗和内放射治疗。结论:目前钇90微球放射栓塞治疗肝脏恶性肿瘤是重要研究热点之一,中国的研究人员不仅需要关注该领域的前沿研究,还应积极开展多中心临床研究项目。

Objective:To investigate the global status and development trends of radioembolization for liver cancer with yttrium-90 through bibliometric analysis.Method:All available data of the articles concerning radioembolization for liver cancer with yttrium-90,based on Web of Science database from 1991 to 2021,were analyzed with bibliometric analysis for creating visual knowledge maps of the countries,institutions,authors,journals and keywords by VOS viewer.Result:According to the search strategy and screening criteria,a total of 989 articles related to radioembolization for liver cancer with yttrium-90 were included in this study,involving 4406 researchers from 1055 institutions in 47 countries.The overall number of annual and cumulative publications significantly showed an upward trend,reaching a peak in 2021.United States dominated in national cooperation and number of articles.The top three institutions of total publications were Northwestern University,University of Navarra and Washington University.The top three authors of total publications and citations were Salem R,Lewandowski RJ and Mulcahy MF.Journal of Vascular and Interventional Radiology and other journals have played a vital role in promoting the development of this field.The top 10 keywords with occurrence frequency were radioembolization,hepatocellular carcinoma,yttrium-90,Y-90 microspheres,survival,cancer,liver metastases,microspheres,selective internal radiation therapy and internal radiation therapy.Conclusion:Radioembolization for liver cancer with yttrium-90 is one of the important research hotspots of liver cancer.Chinese researchers should not only pay attention to the frontier research in this field,but also actively carry out multicenter clinical research projects.