胰腺肿瘤干细胞标记物的研究进展

Research progress of pancreatic cancer stem cell markers

胰腺癌是一种侵袭性恶性肿瘤,有很高的远处转移率、复发率及致死率。近年研究发现,肿瘤组织中的肿瘤干细胞(CSCs)在肿瘤的发生、发展、转移、复发以及耐药中起着重要作用。CSCs标记物对肿瘤临床诊断及预后分析有潜在价值,并可能是潜在的治疗靶点。胰腺癌预后不良可能由胰腺CSCs的存在引起的,因此,对胰腺CSCs的研究与鉴定将有助于胰腺癌发病机制的认识与新疗法的推出。

Pancreatic cancer is a highly invasive and malignant tumor with a significant propensity for distant metastasis,recurrence,and a high fatality rate.Recent research has revealed that cancer stem cells(CSCs)in the tumor tissue play a critical role in the initiation,development,metastasis,recurrence,and resistance to treatment of the cancer.The markers of CSCs hold potential value for clinical diagnosis and prognosis analysis of tumors and may serve as potential therapeutic targets.The dismal prognosis of pancreatic cancer may be attributed to the presence of pancreatic CSCs.Therefore,the study and identification of pancreatic CSCs will contribute to a better understanding the mechanisms underlying pancreatic cancer and the development of new treatment approaches.