湖湘名中医治疗胃脘部病证用药规律数据挖掘研究

Medication rule of famous Chinese medicine practitioners in Hunan Province of China in treatment of epigastric diseases:A study based on data mining

目的:通过数据挖掘方法分析湖南省名中医治疗胃脘部病证的处方用药规律。方法:对湖南省中医药管理局评选出的四批共174位“湖南省名中医”的专科方向进行统计,选取专业方向为“中医内科学”的名中医,收集其治疗胃脘部病证的文献,筛选相关处方,建立数据库。通过古今医案云平台进行药物频数统计、关联规则分析、系统聚类、因子分析及复杂网络构建。结果:174位湖南省名中医中有84位专业方向为“中医内科学”。通过中国知网(CNKI)收集到相关文献60篇,处方137首;相关书籍10本,处方87首。删除重复处方22首,共纳入处方202首,包含中药237味。药物使用频次排名前5位的依次为甘草、法半夏、陈皮、茯苓、柴胡,药性多为温、平、微寒,药味多为辛、甘、苦,多归脾、胃、肺经,功效以燥湿化痰、清热解毒、行气止痛、疏肝解郁、补脾益气为主。药物关联分析结果显示,支持度最高的3组药物均由陈皮、法半夏、茯苓组成,其共现度均为35;疾病-药物关联分析共得到38条关联规则。对高频中药进行因子分析和聚类分析,得到9个公因子和6个类方。复杂网络分析分别提取到治疗胃脘痛、痞满与呕吐的核心组方各1个。结论:湖南省名中医治疗胃脘部病证的用药特点为寒温并用,消补兼施,肝脾同调,将健运脾胃与疏肝理气相结合,并注重身心同治。

Objective:To investigate the prescription and medication rules of famous Chinese medicine practitioners in Hunan Province of China in the treatment of epigastric diseases based on data mining.Methods:A statistical analysis was performed for the specialty of 174“famous Chinese medicine practitioners in Hunan Province”selected by Administration of Traditional Chinese Medicine of Hunan Province,and the famous Chinese medicine practitioners with the specialty of“internal medicine of traditional Chinese medicine”were selected to collect their articles on the treatment of epigastric diseases;related prescriptions were screened to establish a database.Cloud Platform of Ancient and Modern Medical Records was used to perform frequency statistics,association rule analysis,hierarchical clustering,factor analysis,and complex network construction.Results:Among the 174 famous Chinese medicine practitioners in Hunan Province,84 had the specialty of“internal medicine of traditional Chinese medicine”.CNKI was searched to obtain 60 articles involving 137 prescriptions and 10 books involving 87 prescriptions.After 22 repeated prescriptions were removed,202 prescriptions were included in the analysis,which contained 237 traditional Chinese medicine(TCM)drugs.The top five TCM drugs in terms of frequency of use was Radix Glycyrrhizae,Rhizoma Pinelliae Praeparatum,tangerine peel,Poria cocos,and Bupleurum chinense;most drugs were warm,neutral,or slightly cold in nature and had a pungent,sweet,or bitter taste,and they mainly entered the spleen,stomach,and lung meridians;the main functions of these drugs included drying dampness and eliminating phlegm,clearing heat and detoxicating,moving Qi and relieving pain,soothing the liver and resolving stagnation,and tonifying the spleen and benefiting Qi.The drug association analysis showed that the top three combinations of drugs with the highest degree of support were all composed of tangerine peel,Rhizoma Pinelliae Praeparatum,and Poria cocos,with a co-occurrence of 35,and the disease-drug association analysis obtained 38 association rules.Factor analysis and cluster analysis were performed for high-frequency TCM drugs and obtained 9 common factors and 6 associated prescriptions.The complex network analysis obtained one core prescription for epigastric pain,one for stuffiness and fullness,and one for vomiting.Conclusion:Famous Chinese medicine practitioners in Hunan Province use both cold and warm drugs in the treatment of epigastric diseases,emphasize both reinforcing and eliminating,regulate both the liver and the spleen,and combine the method of invigorating and activating the spleen and the stomach with the method of soothing the liver and regulating Qi,while paying attention to the treatment of both the body and the mind.