创伤性脑损伤与肠道菌群关系研究进展

Advances in Relationship between Traumatic Brain Injury and Intestinal Flora

创伤性脑损伤是一种高致死率的疾病,严重危害人类生命健康。肠脑轴是大脑和胃肠道系统之间主要的双向通讯途径。近年来,创伤性脑损伤与肠道菌群的相互作用关系逐渐被揭示。肠道菌群通过肠脑轴参与了创伤性脑损伤后急性病理损伤的调节过程并发挥重要作用。本文综述了创伤性脑损伤的发生、对人类健康的巨大影响,肠脑轴的含义及其在颅脑损伤中的病理调节机制,并在此基础上提出可能的治疗手段,包括粪便微生物菌群移植、使用益生菌、刺激迷走神经、摄入多酚类物质以及靶向免疫调节策略,以期为临床治疗创伤性脑损伤提供新的思路。

Traumatic brain injury is a disease with high mortality rate,which seriously endangers human life and health.Gut brain axis is the main two-way communication pathway between brain and gastrointestinal system.Recently,the interaction between traumatic brain injury and intestinal flora has been gradually revealed.Intestinal microbial population participates in the regulation of acute pathological injury after traumatic brain injury through intestinal brain axis and plays an important role.This paper reviews the occurrence of traumatic brain injury,its great impact on human health,the meaning of intestinal brain axis and its pathological regulation mechanism in craniocerebral injury.On this basis,this paper discusses and puts forward possible treatments,including fecal microbiota transplantation,probiotics,vagus nerve stimulation,intake of polyphenols and targeted immune regulation strategies,so as to provide new ideas for the clinical treatment of traumatic brain injury.