职业紧张和血脂异常对高血压患病的交互作用

Interaction abetween occupational stress and dyslipidemia on the prevalence of hypertension

目的探讨职业紧张和血脂异常的交互作用与高血压患病的关系。方法(1)采用随机整群抽样方法,最终纳入克拉玛依8所油田分公司的2149名油田工人作为研究对象,发放付出-回报失衡(effort-return imbalance,ERI)量表并收集体检指标,最终纳入研究对象。(2)通过logistic回归分析模型和Delta法分析职业紧张和血脂异常交互作用与高血压患病的关系。结果高血压患病率为27.3%,职业紧张和血脂异常组的高血压患病率均较高(均P<0.05);校正混杂因素后,职业紧张(OR=1.243,95%CI:1.027~1.505,P=0.025)和血脂异常(OR=2.089,95%CI:1.712~2.548,P<0.001)是高血压的危险因素,两者与高血压存在相加[交互作用超额相对危险度(relative excess risk of interaction,RERI)=5.556,交互作用归因比(attributable proportion of interaction,API)=0.649,交互作用指数(synergy index,S)=3.774]和正的相乘交互作用(OR=2.327,95%CI:1.755~3.085,P<0.001);职业紧张和血脂异常同时存在罹患高血压的风险是两者均不存在者的8.6倍(95%CI:6.443~11.371)。结论职业紧张、血脂异常及其交互作用均与高血压的患病风险增加有关。

Objective This study aimed to investigate the interaction between occupational stress and dyslipidemia on the prevalence of hypertension.Methods Using cluster sampling,the study selected 2149 oilfield workers from eight Karamay oilfield branches.Participants′occupational stress was investigated using the Effort-Reward Imbalance(ERI)scale,and their physical indicators were also assessed.Logistic regression analysis and Delta method were used to determine the association between the interaction of occupational stress and dyslipidemia and hypertension prevalence.Results The prevalence of hypertension was found to be 27.3%.The prevalence of hypertension was significantly higher both in the occupational stress group and dyslipidemia group(all P<0.05).After adjustment for confounding factors,logistic regression analysis showed that occupational stress(OR=1.243,95%CI:1.027-1.505,P=0.025)and dyslipidemia(OR=2.089,95%CI:1.712-2.548,P<0.001)were independently associated with the risk of hypertension.Occupational stress and dyslipidemia had additive(RERI=5.556,API=0.649,S=3.774)and positively multiplicative(OR=2.327,95%CI:1.755-3.085,P<0.001)interaction on hypertension.Occupational stress combined with dyslipidemia was􀅰associated with 8.6 times higher risk compared to the group without occupational stress and dyslipidemia.Conclusions Occupational stress,dyslipidemia and their interaction were associated with an increase risk of hypertension.