肠道菌群与妊娠期糖代谢相关性及益生菌应用相关研究进展

The correlation between intestinal flora and glucose metabolism during pregnancy and the research progress on the application of probiotics

肠道菌群是居住在人体肠道黏膜表面的微生物群, 在正常妊娠期间随妊娠进展肠道菌群构成可发生动态改变;妊娠糖尿病是一种常见妊娠并发症, 可影响母婴肠道菌群, 通过增加胰岛素抵抗、引发炎症反应等机制影响母婴远期糖代谢。通过饮食结构调整及益生菌应用可能调节肠道微生物群, 改善妊娠糖尿病母婴糖代谢状况。文章综述了肠道菌群与妊娠期糖代谢的相关性, 并讨论了饮食及益生菌对肠道菌群的影响。

Gut microbiota is the microbial community that resides on the surface of human intestinal mucosa.During normal pregnancy,the composition of gut microbiota may change dynamically with the progress of pregnancy.Gestational diabetes mellitus(GDM)is a common complication of pregnancy,which can affect maternal and neonatal intestinal flora,and affect the long-term glucose metabolism of mothers and infants through exacerbating insulin resistance and promoting inflammatory response.Adjustment of dietary structure and application of probiotics may regulate intestinal microbiota and improve maternal and neonatal glucose metabolism in GDM.Here we reviewed the correlation between intestinal flora and glucose metabolism during pregnancy,and discussed the effects of diet and probiotics on gut microbiota.