难治性艾滋病相关性卡波西肉瘤的治疗现状

Actuality and advance of the treatment about the refractory AIDS⁃associated Kaposi's sarcoma

卡波西肉瘤(KS)是一种艾滋病(AIDS)相关的恶性肿瘤,与卡波西肉瘤相关疱疹病毒(KSHV)感染有关。KS是AIDS患者最常见的临床表现之一,是一种AIDS指征性疾病。联合抗反转录病毒治疗是首选治疗方案。局部治疗主要用于KS的局灶病变。全身治疗主要针对局部侵袭性和播散性卡波西肉瘤,推荐药物是阿霉素脂质体和紫杉醇脂质体。免疫治疗与靶向治疗目前尚处于发展阶段。

Kaposi's sarcoma(KS),in relation to the infection by KS⁃associated herpes virus(KSHV),is an acquired immune deficiency syndrome(AIDS)⁃related malignant tumor.As an AIDS indicative disease,KS is one of the most common clinical manifestations of AIDS patients.Combination antiretroviral therapy is the first choice of treatment.Topical treatment is mainly used for focal lesions of KS.Systemic treatment for locally invasive and disseminated KS is recommended with doxorubicin liposome and paclitaxel liposome.Immunotherapy and targeted therapy are still in the development stage.