剖宫产与常见儿童神经发育障碍相关性新进展

New advances in the relationship between cesarean section and common neurodevelopmental disorders in children

近年来全世界范围内剖宫产率持续升高。虽然剖宫产在某些情况下可以拯救生命,但有研究表明剖宫产对儿童健康有不利影响,如增加哮喘和肥胖风险。剖宫产对儿童神经发育的影响也逐渐受到关注,其机制可能与微生物、压力、激素暴露有关。本文对剖宫产与孤独症谱系障碍、注意缺陷多动障碍和学习障碍的相关性和发病机制进行了综述。

Worldwide,cesarean section(CS)rates continue to increase.Although a CS can be a life⁃saving intervention when medically indicated,observational studies have shown that CS is associated with certain adverse health outcomes in children,such as asthma and obesity.Concern has also been raised over possible impacts on neurodevelopment.In this review,we summarize the impact of CS on autism spectrum disorder(ASD),attention deficit hyperactivity disorder(ADHD)and learning disabilities(LD).Furthermore,we also discuss potential mechanisms that link CS with neurodevelopmental disorders,whereas offspring born by CS have different bacterial,physical and hormonal exposures.