新型冠状病毒感染患者QT间期延长及其不良预后的研究进展

Advances in research of QT interval prolongation and poor prognosis among patients with corona virus disease 2019

近年来,随着新型冠状病毒感染(coronavirus disease 2019,COVID-19)的全球流行,抗病毒感染药物的安全性问题日益引发关注。羟氯喹单用或联用阿奇霉素会导致COVID-19患者心电图QT间期延长,可能具有诱发严重心律失常的风险。国内外的临床证据均显示,对COVID-19患者需要严格监测QT间期的变化。本文对导致COVID-19患者QT间期延长的药物和炎症、年龄等因素及其对预后的影响进行综述,为临床医生优化COVID-19患者的治疗方案提供参考。

In recent years,with the worldwide pandemic of corona virus disease 2019(COVID-19),the safety of anti-infection drugs arouses more and more attention.Hydroxychloroquine alone or combined with azithromycin could cause prolonged QT interval in the ECGs of patients with COVID-19,which may induce severe arrhythmia.According to the clinical evidences reported at home and abroad,the changes of QT interval in COVID-19 patients should be strictly monitored.This paper reviews on the drugs leading to prolonged QT interval,inflammation,age and other factors in COVID-19 patients,and their impact on the prognosis,in order to provide references for clinicians to optimize the treatment options of COVID-19 patients.