微卫星高度不稳定或错配修复缺陷结直肠癌新辅助免疫治疗的探讨和展望

Exploration and Perspectives of Neoadjuvant Immunotherapy for Microsatellite Instability-High or Mismatch Repair-Deficient Colorectal Cancer

微卫星高度不稳定(microsatellite instability-high,MSI-H)或错配修复缺陷(mismatch repair-deficient,dMMR)结直肠癌对传统新辅助治疗方案的敏感性较低,免疫治疗的出现改变了MSI-H/dMMR结直肠癌的治疗格局。从晚期疾病的后线治疗到一线治疗,甚至在早期结直肠癌的新辅助治疗,免疫治疗均展现出优异的疗效。全文探讨了结直肠癌新辅助免疫治疗的最新研究进展、目前存在的问题以及未来的发展方向,以期在临床实践过程中为MSI-H/d MMR结直肠癌患者制定个体化治疗方案提供参考。

Microsatellite instability-high(MSI-H)or mismatch repair-deficient(dMMR)colorectal cancer is less sensitive to traditional neoadjuvant regimens.However,the advent of immunotherapy has changed the treatment landscape for MSI-H/dMMR colorectal cancer,demonstrating excellent efficacy from post treatment to first-line treatment of advanced disease,and even for earlystage colorectal cancer.This paper discusses the latest research progress,current problems and future directions of neoadjuvant immunotherapy for MSI-H/dMMR colorectal cancer patients,to provide reference for the development of individualized treatment clinically.