儿童及青少年鼻咽癌研究进展

Research Progress on Nasopharyngeal Carcinoma in Children and Adolescents

我国属鼻咽癌高发区,主要发生于中老年成人患者,儿童及青少年罕见。随着放疗技术进步和综合治疗研究的开展,鼻咽癌疗效和预后发生变化。未成年鼻咽癌发病率低,针对此组患者人群的前瞻性临床试验较少,缺乏诊治及临床管理方面统一的国际指南与标准,主要参考成年患者结果。鉴于未成年鼻咽癌患者处于生长发育阶段,有其独特的临床特点、治疗毒性反应和预后表现,全文对儿童及青少年鼻咽癌的临床表现、诊断、治疗进展及预后进行综述,以期为儿童及青少年鼻咽癌患者的治疗提供参考。

China is a high-incidence area for nasopharyngeal carcinoma,which mainly occurs in middle-aged and elderly adults and is rare in children and adolescents.With the advancement of radiotherapy and comprehensive therapy,the efficacy and prognosis of nasopharyngeal carcinoma have changed.The incidence of juvenile nasopharyngeal carcinoma is low,there are few prospective clinical trials for this group of patients,and there is a lack of unified international guidelines and standards of diagnosis,treatment and clinical management for juvenile nasopharyngeal carcinoma,which usually follow those of adult patients.In view of the fact that juvenile nasopharyngeal carcinoma patients are in the growth and development stage,with their unique clinical characteristics,adverse effects of treatment and prognosis,this paper reviews the clinical manifestations,diagnosis,treatment progress and prognosis of nasopharyngeal carcinoma in children and adolescents to provide reference for clinical application.