中晚期结直肠癌患者健康相关生活质量及影响因素分析

Health-related Quality of Life and Its Influencing Factors in Patients with Advanced Colorectal Cancer

[目的]了解中晚期结直肠患者健康相关生活质量及其影响因素。[方法]研究来自一项全国多中心研究,按照全国人口数以及结直肠癌的患病率采用分层、随机抽样的方式抽取277例结直肠癌患者,在包头市、赤峰市、巴彦淖尔市等地医院对中晚期结直肠癌患者进行问卷调查。问卷内容包括患者基本情况、患者生活质量以及其影响因素。采用EpidataV.3.1软件进行数据录入、双核对。采用SPSS25.0进行统计学分析。[结果]中晚期结直肠癌患者总体生活质量得分为137.52±14.87。不同职业、就诊医院个数、是否使用靶向药物在健康相关生活质量方面差异有统计学意义,其中机关及企事业单位人员、就诊医院个数≥3家的患者生活质量评分较高,其余差异未见统计学意义。不同就诊医院个数、治疗方式在社会家庭方面评分差异有统计学意义,其中就诊医院个数≥3家、手术+化疗+放疗治疗方式的患者社会家庭情况评分较高。是否做肠镜筛查的患者在情感状况方面差异有统计学意义,其中未做肠镜筛查患者的情感状况评分较高。不同疾病分期、就诊医院个数、是否使用靶向药物在功能状况方面评分差异有统计学意义,其中Ⅲ期患者、就诊医院个数≥3家以及未使用靶向药物患者的功能状况评分较高。多因素分析结果显示,职业、治疗方式以及就诊医院个数是中晚期结直肠癌患者生活质量的主要影响因素。[结论]结直肠癌患者生活质量处于较低水平,职业、就诊医院数量、治疗方式是主要影响因素,应从经济、社会、家庭等多方面对患者予以关注。

[Purpose]To analyze the health-related quality of life and its influencing factors in advanced colorectal patients.[Methods]Based on the national multi-center study,a questionnaire survey on health-related quality of life was conducted among 277 patients with advanced colorectal cancer selected by stratified random sampling method from 4 tertiary hospitals in Inner Mongolia Autonomous Region.The questionnaire included the basic information,quality of life of patients and its influencing factors.Epidata V.3.1 software was used for data entry and dual core pair.SPSS 25.0 was used for statistical analysis.[Results]The overall quality of life score of patients with advanced colorectal cancer was 137.52±14.87.There were significant differences in health-related quality of life among patients with different occupations,number of visited hospitals and use of targeted drugs;patients working in government offices,enterprises and public institutions,and those with visited hospitals≥3 had higher quality of life scores.Patients having visited hospitals≥3 and treated with surgery+chemotherapy+radiotherapy had higher social and family scores.Patients who did not undergo colonoscopy screening had a higher emotional status score.Patients with stageⅢcancer,visited hospitals≥3 and not use of targeted drugs had higher functional status scores.Multivariate analysis showed that occupation,treatment methods and number of visited hospitals were the independent factors affecting the quality of life of patients with advanced colorectal cancer.[Conclusion]The quality of life of patients with advanced colorectal cancer is at a low level,and occupation,number of visited hospitals and treatment methods are the main influencing factors.