艾司奥美拉唑治疗急性胃黏膜病变的效果及对胃黏膜防御、损伤相关因子表达的影响

Effect of Esomeprazole in the Treatment of Patients with Acute Gastric Mucosal Lesion and Influence for the Expression of Gastric Mucosal Defense and Injury Related Factors

目的:探究艾司奥美拉唑治疗急性胃黏膜病变(AGML)的效果及对胃黏膜防御、损伤相关因子表达的影响。方法:将2019年9月—2021年2月福建医科大学附属闽东医院的80例严重创伤、大型手术和危重疾病等应激状态下合并AGML患者根据随机数字表法分为对照组40例和观察组40例。对照组进行常规AGML治疗,观察组则在对照组基础上加用艾司奥美拉唑治疗。比较两组AGML治疗总有效率、止血时间、输血量、治疗前后的胃黏膜防御相关因子[促甲状腺激素释放激素(TRH)、三叶因子2(TFF2)、热休克蛋白-70(HSP-70)、碳酸氢根(HCO_(3)^(-))、前列腺素E_(2)(PGE_(2))及一氧化氮(NO)]和胃黏膜损伤相关因子[丙二醛(MDA)、过氧化氢(H_(2)O_(2))和过氧化脂质(LPO)]。结果:观察组的AGML治疗总有效率显著高于对照组,止血时间显著短于对照组,输血量显著少于对照组,差异均有统计学意义(P<0.05),治疗前两组胃黏膜防御、损伤相关因子指标比较,差异均无统计学意义(P>0.05),治疗3、5 d后观察组胃黏膜防御相关因子指标均显著高于对照组,损伤相关因子指标均显著低于对照组,差异均有统计学意义(P<0.05)。结论:艾司奥美拉唑治疗AGML的效果较好,且可有效改善胃黏膜防御及损伤相关因子的表达。

Objective:To investigate the effect of Esomeprazole in the treatment of patients with acute gastric mucosal lesion(AGML)and influence for the expression of gastric mucosal defense and injury related factors.Method:A total of 80 patients with AGML under stress conditions such as severe trauma,major surgery and critical disease in Mindong Hospital Affiliated to Fujian Medical University from September 2019 to February 2021 were divided into the control group with 40 cases and the observation group with 40 cases according to the random number table method.The control group were treated with routine treatment for AGML,the observation group were treated with Esomeprazole on the basis of the control group.Then the total effective rates of AGML treatment,hemostasis time,blood transfusion volume,gastric mucosal defense related factors[thyrotropin-releasing hormone(TRH),trefoil factor family 2(TFF2),heat shock protein-70(HSP-70),bicarbonate radical(HCO_(3)^(-)),prostaglandin E_(2)(PGE_(2))and nitric oxide(NO)]and gastric mucosal injury related factors[malondialdehyde(MDA)and hydrogen peroxide(H_(2)O_(2))and lipid peroxide(LPO)]before and after the treatment of two groups were compared.Result:The total effective rate of AGML treatment in the observation group was significantly higher than that in the control group,the hemostasis time of the observation group was significantly shorter than that of the control group,the blood transfusion volume of the observation group was significantly less than that of the control group,the differences were statistically significant(P<0.05),the gastric mucosal defense and injury related factors of two groups before the treatment were compared,the differences were not statistically significant(P>0.05).The gastric mucosal defense related factors of the observation group after 3 and 5 days of the treatment were significantly higher than those of the control group,and the injury related factors were significantly lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Esomeprazole in the treatment of patients with AGML is better,and it can effectively improve the expression of gastric mucosal defense and injury related factors.