度拉糖肽在糖尿病肾病中的应用效果及对肾功能的影响

Application Effect of Dulaglutide in Diabetic Nephropathy and Its Effect on Renal Function

目的:探讨度拉糖肽在糖尿病肾病中的应用效果及对肾功能的影响。方法:选取2021年1月—2022年1月于太仓市第一人民医院接受治疗的84例糖尿病肾病患者为研究对象,使用随机数字表法将其分为对照组及观察组,各42例。对照组采用常规治疗,观察组在对照组基础上加用度拉糖肽注射液治疗。对比两组治疗总有效率、血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、肾功能指标[24 h尿微量白蛋白定量、尿微量白蛋白/肌酐比值、血肌酐(Scr)、肾小球滤过率(GFR)]、血清相关因子[组织型金属蛋白酶抑制剂-1(TIMP-1),转化生长因子β_(1)(TGF-β_(1))、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组FPG、2 h PG、HbA1c、24 h尿微量白蛋白定量、尿微量白蛋白/肌酐比值、Scr、TGF-β_(1)、IL-6、TNF-α均较治疗前降低,且观察组上述指标均低于对照组;两组GFR均较治疗前上升,且观察组高于对照组,TIMP-1均较治疗前下降,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:度拉糖肽能够显著降低糖尿病肾病患者血糖水平,优化肾功能,缓解肾纤维化、减轻炎症反应。

Objective:To explore the application effect of Dulaglutide in diabetic nephropathy and its effect on renal function.Method:From January 2021 to January 2022,84 cases of diabetic nephropathy treated in the First People's Hospital of Taicang were selected as the research objects.They were divided into the control group and the observation group by using the random number table method,with 42 cases in each group.the control group was treated with conventional treatment,the observation group was treated with Dulaglutide Injection on basis of the control group.The total treatment effective rate,blood glucose indexes[fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 h PG),glycosylated hemoglobin(HbA1c)],renal function indexes[24 h urine microalbumin quantification,urine microalbumin/creatinine ratio,serum creatinine(Scr),glomerular filtration rate(GFR)]and serum related factors[tissue type inhibitor of metalloproteinase-1(TIMP-1),transforming growth factorβ_(1)(TGF-β_(1)),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]of the two groups were compared.Result:The total treatment effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,FPG,2 h PG,HbA1c,24 h urine microalbumin quantification,urine microalbumin/creatinine ratio,Scr,TGF-β_(1),IL-6,and TNF-αin the two groups were lower than those before treatment,the above indexes in the observation group were lower than those in the control group;the levels of GFR in the two groups were higher than those before treatment,and that in the observation group was higher than that in the control group,the levels of TIMP-1 in the two groups were lower than those before treatment,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Dulaglutide can significantly reduce blood glucose level in patients with diabetic nephropathy,optimize renal function,alleviate renal fibrosis,and reduce inflammatory response.