肠宁舒颗粒联合美沙拉嗪治疗溃疡性结肠炎临床效果观察

Clinical observation of Changningshu granules combined with mesalazine in the treatment of ulcerative colitis

目的探讨肠宁舒颗粒联合美沙拉嗪治疗溃疡性结肠炎(UC)的临床效果。方法选取解放军联勤保障部队901医院自2019年5月至2022年5月收治的80例轻中度UC患者为研究对象。采用随机数字表法将患者分为A组与B组,每组各40例。A组患者给予美沙拉嗪治疗,B组患者给予美沙拉嗪联合肠宁舒颗粒治疗。两组患者均治疗4周。比较两组患者的临床效果、临床症状消失时间和不良反应发生情况。记录并比较两组患者治疗前后血清炎性因子水平,包括白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)。结果B组患者治疗的总有效率为95.0%(38/40),高于A组的72.5%(29/40),差异有统计学意义(P<0.05)。B组患者里急后重、脓血便、泄泻和腹痛症状消失时间均短于A组,差异均有统计学意义(P<0.05)。治疗后4周,两组患者WBC、CRP、PCT、IL-6均低于治疗前,且B组均低于A组,差异均有统计学意义(P<0.05)。A组、B组患者不良反应总发生率分别为5.0%(2/40)、2.5%(1/40),差异无统计学意义(P>0.05)。结论肠宁舒颗粒联合美沙拉嗪治疗UC疗效确切,可改善患者的临床症状及炎性因子水平,且安全性较高。

Objective To investigate the clinical effect of Changningshu granule combined with mesalazine in the treatment of ulcerative colitis(UC).Methods A total of 80 mild to moderate UC patients admitted to the 901 Hospital of the PLA Joint Logistic Support Force from May 2019 to May 2022 were selected as subjects.The patients were divided into group A and group B by random number table method,with 40 cases in each group.Group A was treated with mesalazine,group B was treated with mesalazine combined with Changningshu granules.Two groups of patients were treatment of 4 weeks.The clinical effect,duration of clinical symptom disappearance and occurrence of adverse reactions were compared between the two groups.Serum inflammatory factors,including white blood cell count(WBC),C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6),were recorded and compared between the two groups before and after treatment.Results The total effective rate of treatment group B patients was 95.0%(38/40),72.5%(29/40)is higher than that in group A,the difference was statistically significant(P<0.05).The disappearance time of posterior gravity,pus and blood stool,diarrhea and abdominal pain in group B was shorter than that in group A,and the differences were statistically significant(P<0.05).4 weeks after treatment,WBC,CRP,PCT and IL-6 in 2 groups were lower than before treatment,and group B was lower than group A,with statistical significance(P<0.05).The total incidence of adverse reactions in group A and group B was 5.0%(2/40)and 2.5%(1/40),respectively,with no statistical significance(P>0.05).Conclusion Changningshu granule combined with mesalazine is effective in the treatment of UC,and can improve the clinical symptoms and inflammatory factors of patients,with high safety.