三氟草嗪的合成与除草活性

Synthesis and Bioactivity of Trifludimoxazin

三氟草嗪是一种新型高效的三嗪酮类除草剂。本研究以2-溴-2,2-二氟乙酸乙酯和二乙胺为起始原料经6步反应合成了三氟草嗪,目标化合物的结构经1H NMR确证。试验结果表明,目标化合物三氟草嗪的收率达82%,三氟草嗪对百日草、苘麻、金色狗尾草和稗草均具有优异的除草活性,在有效成分为9.375 g/hm^(2)时,对百日草和苘麻的防效可达到95%和100%。本研究对三嗪酮类化合物的工艺开发或结构优化提供参考。

Trifludimoxazin is a new and effective triazinone herbicide.Trifluoxazine was synthesized in six steps by starting the reaction from 2-bromo-2,2-difluoroacetate ethyl ester and diethylamine.The structure of the target compound was confirmed by 1H NMR.The results showed that the yield of trifludimoxazin was 82%,and trifludimoxazin had excellent herbicidal activity against the Zinnia elegans Jacq,Abutilon theophrasti Medic,Setaria glauca(L.)Beauv and Echinochloa crus-galli(L.)Beauv.The herbicidal activity of trifludimoxazin against the Z.elegans and A.theophrasti was 95%and 100%at the dosage of 9.375 g/hm^(2).This research provided the basis for process development and tructure optimization of trifludimoxazin.