Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery

A wide range of polymer-based drug delivery systems have been reported for the treatment of variousdiseases.However,the dosing regimen of many drugs,such as stimulator of interferon genes agonists,programmed cell death protein-1 antibodies,and coronavirus disease 2019 vaccines,consists of repeatedintratumoral or intramuscular injections.These repeated administrations may lead to poor adherence,thus resulting in compromised therapeutic outcomes and increased financial burden.Here,we developed a multidose drug delivery platform by engineering polylactic-co-glycolic acid(PLGA)with differentmolecular weights into self-healing single-cavity microcapsules(SSM).This approach showed a flexiblecollocation strategy to achieve customized pulsatile drug release and was fully degradable with goodsafety.Notably,this single-injection delivery system contains only PLGA,holding great promise forclinical translation.