抗肿瘤药物联合疗法价值归因探索

Study on the Value Attribution of Antitumor Drug Combination Therapy

目的:准确评估抗肿瘤药物联合疗法及组成联合疗法的各药物价值。方法:详细介绍价值归因的原理及使用条件。结果:总结基于各单药疗效比值的归因、基于边际价值的归因和分段分配价值归因三种基本价值归因类型及相关变型,在此基础上进一步对比分析不同情况下各价值归因方法的结果,给出选择思路。结论:价值归因应用具有独特优势,也存在局限性,应全方位收集证据,进一步完善方法,权衡各方利益谨慎选择适用方法,最终构建适合我国的特色价值归因体系。

Objective To accurately evaluate anti-tumor drug combination therapy and the value of various drugs those make up the combination therapy.Methods The principle and usage conditions of value attribution were introduced in detail.Results This article summarized three basic types of value attribution,including attribution based on the benefit ratio of each single drug,attribution based on marginal value,and attribution based on segmented allocation value,as well as related variants.On this basis,this article further compared and analyzed the results of various value attribution methods in different situations,and provided selection ideas.Conclusion The application of value attribution has unique advantages and limitations.It is necessary to collect evidence from all aspects,further improve methods,weigh the interests of all parties,and carefully choose applicable methods,ultimately construct a unique value attribution system suitable for China.