泛凋亡在急性肺损伤/急性呼吸窘迫综合征中的研究进展

Research advances of PANoptosis in acute lung injury/acute respiratory distress syndrome

程序性细胞死亡主要包括焦亡、凋亡和坏死性凋亡等途径, 在宿主防御病原体入侵和维持体内平衡中发挥重要作用。虽然之前的研究认为各种程序性细胞死亡之间是相互独立的通路, 但随着研究的深入, 越来越多的证据表明各程序性细胞死亡之间存在广泛的相互作用, 研究者把各程序性细胞死亡通路之间存在的串扰现象称为泛凋亡(PANoptosis), 且PANoptosis受到上游泛凋亡小体复合物(PANoptosome)调控。文章通过对PANoptosis及PANoptosome的成分来源、刺激因素、形成机制以及在急性肺损伤(acute lung injury, ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)中的研究进展进行描述, 旨在为ALI/ARDS的预防和治疗提供更广泛的思路。

Programmed cell death mainly includes pyroptosis,apoptosis,necroptosis,and other pathways,which play an important role in host defense against pathogen invasion and maintaining homeostasis.Although previous studies have believed that various programmed cell death pathways are independent pathways.Recently increasing evidence pointed to complex crosstalk between these signaling pathways.This process is termed PANoptosis,and it is regulated by upstream PANoptosome.In this review,we aim to provide a broader perspective for the prevention and treatment of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)by describing the constituent sources,stimuli,mechanisms of formation and progress of PANoptosis and PANoptosome complex.