PIKfyve的生物学功能及与疾病的关系

Biological function of PIKfyve and its relationship with diseases

含FYVE结构的磷酸肌醇3-磷酸5-激酶(FYVE domain-containing phosphatidylinositol 3-phosphate5-kinase,PIKfyve)是哺乳动物体内的一种磷脂酰肌醇脂质激酶。PIKfyve通过催化磷脂酰肌醇-3-磷酸[phosphatidylinositol 3-phosphate,PtdIns(3)P]生成磷脂酰肌醇-3,5-二磷酸[phosphatidylinositol-3,5-bisphosphate,PtdIns(3,5)P2]或磷脂酰肌醇-5-磷酸[phosphatidylinositol-5-phosphate,PtdIns(5)P],在调节膜运输以及维持溶酶体功能中发挥关键作用,还参与内体转运、转录调控和免疫调节等重要细胞生物学功能。近年来的研究表明,PIKfyve在炎症、病原微生物感染、神经退行性疾病和肿瘤的发生发展中起重要作用,可作为潜在的疾病防治靶点。本文就PIKfyve的生化特点、生物学功能及其在相关疾病中发挥的作用研究进展进行综述。

FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase(PIKfyve)is a phosphatidylinositol lipid kinase in mammalian that produces phosphatidylinositol-3,5-bisphosphate[Ptdins(3,5)P_(2)]or phosphatidylinositol-5-phosphate[PtdIns(5)P]by catalyzing phosphatidylinositol-3-phosphate[PtdIns(3)P].It plays a critical role in regulating membrane transport and maintaining lysosomal function,and is also involved in intracellular transport,transcriptional regulation,and immune regulation,among many other important cellular biological functions.Recent studies have shown that PIKfyve plays an important role in inflammation,pathogenic microbial infections,neurodegenerative diseases,and tumor development,makes it a potential target for disease prevention and treatment.This paper reviews the biochemical characteristics of PIKfyve,its biological functions and its role in related diseases.