雌激素受体α甲基化与肾系相关疾病

Relationship between estrogen receptor ERa on methylation and renal related diseases

雌激素作为一种重要的生理激素,与许多疾病的发生发展有关。近年来研究发现,雌激素通过雌激素受体对肾脏有调节作用。雌激素受体α(estrogen receptor alpha,ERα)在体内肾脏相关区域有多处分布,而雌激素受体甲基化异常会影响雌激素对肾脏的调节作用,导致骨质疏松、糖尿病肾病等多种肾脏相关疾病的发生。本文总结了ERα的生理结构和甲基化进程以及对部分肾脏疾病的研究进展,希望通过阐明ERα甲基化对肾脏疾病的调节作用,发现不同肾脏疾病的交叉通路蛋白之间的相互影响机制,为临床治疗提供进一步的理论支持。

As an important physiological hormone,estrogen is related to the occurrence and development of many diseases.In recent years,studies have found that estrogen can regulate the kidney through estrogen receptor.Estrogen receptor α distributed in multiple areas related to the kidneys in the body,and the abnormal methylation of estrogen receptor will affect the regulation of estrogen on the kidney,leading to osteoporosis,diabetes nephropathy and other kidney related diseases.This paper summarizes ERa the physiological structure,methylation process,and research progress on some kidney diseases,in order to elucidate ERa the regulatory effect of methylation on renal diseases and the discovery of the interaction mechanism between cross pathway proteins of different kidney diseases,provide further theoretical support for clinical treatment.