靶向p53信号通路在癌症治疗中的作用

Roles of targeting p53 signaling pathway in cancer treatment

作为一种肿瘤抑制因子,p53可协调多种反应,包括细胞周期阻滞、DNA修复、抗氧化作用、抗血管生成作用、自噬、衰老和凋亡等。p53主要通过调节其靶基因的转录发挥其肿瘤抑制功能,但p53是癌症中最常见的突变基因之一,当p53发生突变时,就会导致其功能丧失进而导致肿瘤细胞生长。p53已成为癌症治疗中最重要和最有吸引力的药物靶点之一,因此以p53为靶点产生了许多癌症治疗方式。本文回顾了靶向p53信号通路在基因治疗、靶向治疗以及免疫治疗中的研究,以期为了解靶向p53的研究提供新思路。

As a tumor suppressor,p53 can coordinate a variety of reactions,including cell cycle arrest,DNA repair,anti-oxidation,anti-angiogenesis,autophagy,senescence and apoptosis.p53 exerts its tumor suppressor function mainly by regulating the transcription of its target genes.However,p53 is one of the most common mutant genes in cancer.When p53 mutates,it will lead to the loss of its function and lead to the growth of tumor cells.It has become one of the most important and attractive drug targets in cancer treatment.Therefore,many cancer treatment methods are produced by targeting p53.This article reviews the research of targeted p53 signaling pathway in gene therapy,targeted therapy and immunotherapy,in order to provide new ideas for understanding the research of targeting p53.