摘要
类风湿性关节炎(rheumatoid arthritis,RA)经久不愈易导致关节畸形,影响患者日常生活质量,其发病机制包括肠道微生态失调、短链脂肪酸(short-chain fatty acid,SCFA)、内源性大麻素系统(endogenous cannabinoid system,ECS)以及炎症反应等的交互作用。本文以“菌-肠-关节轴”为主介绍了肠道微生物、SCFA与ECS之间的相互关系以及RA治疗策略的相关进展,旨在为RA的新药研发机制提供新思路。
Rheumatoid arthritis(RA)is a repetitive ictal chronic disease,which easily leads to joint deformity.Thus,the daily life quality of the patients should be affected.RA pathogenesis mainly included the interaction of gut microbial dysbiosis,short-chain fatty acid(SCFA),endogenous cannabinoid system(ECS)and inflammatory reaction.This work reviewed the interaction of gut microbiotas,SCFA and ECS based on the theories of microbiota-gut-joint axis,and introduce the research progress of RA intervene strategies,in order to provide new insight for new drug development mechanism related to RA treatment.
作者
杨杰
YANG Jie(Pharmacological Teaching and Research Section,Department of Fundamental Medicine,Bijie Medical College,Bijie 551700,China)
出处
《生命的化学》
CAS
2023年第9期1423-1430,共8页
Chemistry of Life
基金
贵州省基础研究计划资助项目(黔科合基础[2019]1003)。
