MiRNA调控IGFBPs参与肿瘤发生的研究进展

Research progress on miRNA regulation of IGFBPs involved in tumorigenesis

作为一类广泛存在于真核细胞中的RNA分子,微小RNA(microRNA,miRNA)在生物体内的基因表达调控、生长发育等基本生命过程中发挥着不可替代的重要作用,与人类疾病密切相关。胰岛素样生长因子结合蛋白(insulin-like growth factor binding proteins,IGFBPs)是一类结合和调节胰岛素样生长因子(insulin-like growth factor,IGF)生物活性的蛋白质,在肿瘤中通过IGF依赖或非依赖的机制扮演着至关重要的角色。在肿瘤中,IGFBPs和mi RNA的异常表达与肿瘤细胞的增殖、侵袭和转移等生物学行为密切相关。IGFBPs能够作为mi RNA的直接靶因或者下游信号分子,参与多种疾病的发生与发展。该文总结了mi RNA在脑、胃肠道、肝胆、妇科等多种肿瘤性疾病中对IGFBPs的调控作用,以期为相关疾病的临床诊断、预后生物标志物或治疗靶点等的探索提供全面、专业的参考。

As a class of RNA molecules widely existing in eukaryotic cells,microRNA plays an irreplaceable and important role in the regulation of gene expression,growth and development and other basic life processes in organisms,which is closely related to human diseases.Insulin-like growth factor binding proteins(IGFBPs)is a class of proteins that binds to insulin-like growth factor(IGF)and is involved in the regulation of IGF.It plays an important role in tumors through IGF-dependent or non-IGF-dependent mechanisms.The abnormal expression of IGFBPs and miRNA in tumors is closely related to the proliferation,invasion and metastasis of tumor cells.IGFBPs act as direct target genes or downstream signaling molecules of miRNAs and are involved in the development and progression of various diseases.This review summarizes the regulatory effects of miRNA on IGFBPs in various of neoplastic diseases such as brain,gastrointestinal tract,hepatobiliary,and gynecological diseases,with a view to providing a comprehensive and professional reference for the exploration of clinical diagnosis,prognostic biomarkers,or therapeutic targets for related diseases.