摘要
Dear Editor,The X-linked gene cyclin-dependent kinase-like 5(CDKL5)encodes a serine/threonine kinase that is associated with CDKL5-deficiency disorder(CDD),a severe developmental and epileptic encephalopathy characterized by early-onset seizures,gross developmental delay,and motor disabilities[1].The expression of CDKL5 is highly enriched in the brain and is significantly induced during postnatal development[2].
基金
This work was supported by the Ministry of Science and Technology(2018YFA0801404)
the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).
