摘要
Cancer of unknown primary(CUP)is a highly heterogeneous tumor type that is confirmed to be metastatic through pathological examination;however,its primary lesion cannot be determined on the basis of detailed clinical information and diagnostic methods.The current guidelines have not changed the basic definition of CUP.Some studies have reported a decline in the incidence of CUP,to approximately 2%1,with the development of diagnostic techniques such as radiology,histopathology,and genetic testing.
基金
supported by the Natural Science Basic Research Program of Shaanxi(Grant No.2021JZ-35)
the Clinical Research Program of Air Force Medical University(Grant No.2021LC2212)。