河南省7 519名健康人群破伤风抗体水平调查

A survey of tetanus antibody levels in 7 519 healthy people in Henan Province

目的:了解河南省健康人群破伤风抗体水平,为破伤风疫苗免疫策略的调整提供依据。方法:2020—2021年采用多阶段分层抽样法在河南省选择7519名健康人群,采集血清标本,酶联免疫吸附试验检测血清抗破伤风类毒素IgG抗体,分析抗体阳性率(≥0.01 IU/ml)、保护率(≥0.1 IU/ml)和中位数浓度(median concentration,MC)。结果:7519名调查对象破伤风抗体总阳性率、保护率、MC分别为70.33%(5288/7519)、37.07%(2787/7519)、0.035 IU/ml。破伤风疫苗基础免疫和加强免疫均有良好效果。随着年龄的增长,破伤风抗体阳性率、保护率和MC分别由6岁人群的99.63%(272/273)、82.05%(224/273)和0.215 IU/ml下降至16~19岁人群的64.22%(262/408)、21.57%(88/408)和0.023 IU/ml,进一步下降至20岁以上人群的40.97%(1302/3178)、5.48%(174/3178)和0.007 IU/ml。结论:河南省健康人群破伤风抗体水平呈现随年龄增长逐渐下降趋势,建议16~20岁时开展第6剂破伤风疫苗加强免疫。

Objective To analyze tetanus antibody levels in healthy people in Henan Province and to provide reference data for the adjustment of tetanus vaccine immunization strategy.Methods A total of 7519 healthy people were selected using stratified sampling in Henan Province from 2020 to 2021.Serum samples were collected and tested for anti-tetanus toxoid IgG antibody(anti-TT)by ELISA.The positive rate(≥0.01 IU/ml),protection rate(≥0.1 IU/ml)and mean concentration(MC)of anti-TT were analyzed.Results The overall positive rate,protection rate and MC of anti-TT among the 7519 subjects were 70.33%(5288/7519),37.07%(2787/7519)and 0.035 IU/ml,respectively.Both basic and booster tetanus vaccines were effective.The positive rate,protective rate and MC of anti-TT decreased from 99.63%(272/273),82.05%(224/273)and 0.215 IU/ml in 6-year-olds to 64.22%(262/408),21.57%(88/408)and 0.023 IU/ml in 16-to 19-year-olds,and further decreased to 40.97%(1302/3178),5.48%(174/3178)and 0.007 IU/ml in people≥20 years old.Conclusions The level of tetanus antibody decreased with age in healthy people in Henan Province.It was suggested that the sixth dose of tetanus vaccine should to be given at 16-20 years old.