宽胸气雾剂联合非洛地平治疗稳定性心绞痛的临床研究

Clinical study on Kuanxiong Aerosol combined with felodipine in treatment of stable angina pectoris

目的探讨宽胸气雾剂联合非洛地平治疗稳定性心绞痛的临床疗效。方法选取2020年11月—2022年11月文昌市人民医院收治的118例稳定性心绞痛患者,随机法分为对照组(59例)和治疗组(59例)。对照组口服非洛地平片,5 mg/次,1次/d。在对照组的基础上,治疗组口喷宽胸气雾剂,舌下喷2揿/次,3次/d。两组用药28d。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间,6 min步行距离,心绞痛发作次数和持续时间,血清因子血管内皮素-1(ET-1)、同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)和白细胞介素-6(IL-6)水平。结果治疗后,治疗组患者临床有效率(98.31%)明显高于对照组有效率(83.05%,P<0.05)。治疗后,治疗组临床症状改善时间均早于对照组(P<0.05)。治疗后,两组的6 min步行距离明显增加,而心绞痛发作次数和持续时间明显下降(P<0.05),且治疗组这些指标均好于对照组(P<0.05)。治疗后,两组血清因子IL-6、Hcy、ET-1、MMP-9水平比治疗前明显下降(P<0.05),且治疗组患者明显低于对照组(P<0.05)。结论宽胸气雾剂联合非洛地平治疗稳定性心绞痛效果确切,能明显改善胸痛及胸闷等症状,并能有效促进心绞痛发作次数及时间降低,促使炎性反应减弱。

Objective To investigate the therapeutic effect of Kuanxiong Aerosol combined with felodipine in treatment of stable angina pectoris.Methods Patients(118 cases)with stable angina pectoris in Wenchang People's Hospital from November 2020 to November 2022 were randomly divided into control(59 cases)and treatment(59 cases)group.Patients in the control group were po administered with Felodipine Tablets,5 mg/time,once daily.Patients in the treatment group were po administered with Kuanxiong Aerosol on the basis of the control group sublingually,2 press/time,three times daily.Patients in two groups were treated for 28 d.After treatment,the clinical evaluation was evaluated,and the relief time of symptom,6 min walking distance,attacks and duration of angina pectoris,the levels of serum IL-6,Hcy,ET-1 and MMP-9 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group(98.31%)was significantly higher than that of the control group(83.05%,P<0.05).After treatment,the improvement time of clinical symptoms in the treatment group was earlier than that in the control group(P<0.05).After treatment,the 6 min walking distance was significantly increased,while the frequency and duration of angina pectoris were significantly decreased in two groups(P<O.05),and these indexes in the treatment group were better than those in the control group(P<0.05).After treatment,the levels of serum factors IL-6,Hcy,ET-1 and MMP-9 in two groups were significantly lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Felodipine combined with Kuanxiong Aerosol is effective in treatment of chest pain and chest tightness,and can effectively reduce the frequency and time of angina pectoris and weaken the inflammatory reaction.