复方苦参注射液联合TP方案治疗局部晚期宫颈癌的疗效观察

Clinical observation of Compound Kushen Injection combined with TP chemotherapy regimen in treatment of local advanced cervical cancer

目的探讨复方苦参注射液联合TP方案化疗治疗局部晚期宫颈癌的临床疗效。方法选择郑州市第三人民医院2016年9月—2022年10月收治的82例局部晚期宫颈癌患者,随机分为对照组和治疗组,每组各41例。对照组静脉滴注紫杉醇注射液,135~175 mg/m^(2),1次/3周;同时静脉滴注顺铂注射液,75 mg/m^(2)。治疗组在对照组治疗基础上静脉滴注复方苦参注射液,30 mL加入生理盐水250 mL,1次/d,连用14 d。21 d为1个化疗疗程,两组均连续治疗3个疗程。观察两组患者临床疗效,比较治疗前后两组患者中医证候积分和不良反应。结果治疗后,治疗组的客观缓解率(87.80%)与对照组客观缓解率(70.73%)相比明显升高(P<0.05)。治疗后,两组患者阴道出血、带下量、带下色、带下质评分均低于治疗前(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,治疗组不良反应发生率明显低于对照组(P<0.05)。结论复方苦参注射液联合TP方案化疗治疗局部晚期宫颈鳞状细胞癌的临床疗效较好,安全性和可靠性较高。

Objective To investigate the clinical effect of Compound Kushen Injection combined with TP chemotherapy regimen in treatment of local advanced cervical cancer.Methods Patients(82 cases)with local advanced cervical cancer in the Third People's Hospital of Zhengzhou from September 2016 to October 2022 were randomly divided into control and treatment group,and each group had 41 cases.Patients in the control group were iv administered with Paclitaxel Injection,135-175 mg/m^(2),once every three weeks,and they were iv administered with Cisplatin Injection,75 mg/m^(2).Patients in the treatment group were iv administered with Compound Kushen Injection on the basis of the control group,30 mL added into normal saline 250 mL,once daily for 14 d.21 d was one course of chemotherapy,and they were treated continuously for 3 courses.After treatment,the clinical evaluation was evaluated,and the TC syndrome scores,adverse reactions in two groups before and after treatment were compared.Results After treatment,the objective remission rate of the treatment group(87.80%)was significantly higher than that of the control group(70.73%,P<0.05).After treatment,the scores of vaginal bleeding,subband volume,color and quality in two groups were lower than those before treatment(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Compound Kushen Injection combined with TP chemotherapy is effective,safe,and reliable in the treatment oflocally advanced cervical squamous cell carcinoma.