中药党参及黄芪改善肝脏缺血再灌注损伤的机制研究

Study on the mechanism of traditional Chinese medicine codonopsis pilosula and astragalus membranaceus to improve hepatic ischemia-reperfusion injury

肝脏缺血再灌注损伤(HIRI)是指肝脏组织缺血一段时间后血流再次恢复,损伤没有好转,反而进一步加重的现象,临床上常见于失血性休克、肝脏严重创伤手术、肝脏肿瘤切除术、肝脏移植等情况。中药党参和黄芪均有清除氧自由基、抗氧化、保肝等功效,且具有副作用小、毒性低、治疗效果好等优点,临床需更为深入地探析中药党参和黄芪对HIRI的治疗机制,明确党参和黄芪作用机理,以期提升治疗HIRI的针对性。基于此,本文将对中药党参及黄芪改善HIRI的机制进行综述。

Hepatic ischemia-reperfusion injury(HIRI)refers to the phenomenon that the blood flow of the liver is restored after a period of ischemia,and the injury is not improved,but further aggravated.It is commonly seen in hemorrhagic shock,severe liver trauma surgery,liver tumor resection,liver transplantation,etc.Both codonopsis pilosula and astragalus membranaceus have the effects of scavenging oxygen free radicals,antioxidation and liver protection,and have the advantages of small side effects,low toxicity and good therapeutic effect.It is necessary to further explore the therapeutic mechanism of codonopsis pilosula and astragalus membranaceus on HIRI,and clarify the mechanism of action of codonopsis pilosula and astragalus membranaceus,in order to improve the pertinence of HIRI treatment.Based on this,this article will review the mechanism of codonopsis pilosula and astragalus membranaceus to improve HIRI.