PCT、CRP、Mb、CK-MB和cTnI联合检测在轮状病毒性肠炎患儿诊断中的应用价值

Application value of combined detection of PCT,CRP,Mb,CK-MB and cTnl in diagnosis of children with rotavirus enteritis

目的 探究降钙素原(PCT)、C-反应蛋白(CRP)、肌钙蛋白I(cTnI)、肌红蛋白(Mb)和肌酸激酶同工酶(CK-MB)联合检测在轮状病毒性肠炎患儿临床诊断中的价值。方法 将商丘市第一人民医院于2016年4月至2019年6月间收治的164例轮状病毒性肠炎患儿(设为观察组),相同时期的160例细菌感染性肠炎患儿(设为对照组)以及相同时期的116例非感染性肠炎患儿(设为空白组)做对比,比较三种类型的肠炎患儿血清PCT、CRP、Mb、CK-MB和cTnI水平的差异。结果 观察组血清PCT、CRP和CK-MB水平高于对照组和空白组,差异有统计学意义(P<0.01);发病3 d患儿与发病1 d患儿对比,五项指标均升高,差异具有统计学意义(P<0.01)。中重度脱水的患儿相较于无脱水或轻度脱水患儿,其血清Mb、CK-MB和cTnI水平升高。五项指标中,上升幅度较大的患儿,其总病程也有所延长。结论 轮状病毒性肠炎患儿的临床检验指标中,血清PCT、CRP、Mb、CK-MB和cTnI水平联测检测可用于协助诊断疾病,一定程度上可以表征疾病的进展和预后。

Objective To explore the combined detection of procalcitonin(PCT),C-reactive protein(CRP),troponin I(cTnl),myoglobin(Mb)and creatine kinase isoenzyme(CK-MB)and its value of clinical diagnosis in children with viral enteritis.Methods Totally 164 children with rotavirus enteritis admitted in our hospital between April 2016 and June 2019 are set as the observation group,160 children during the same period with bacterial infectious enteritis are set as the control group,and 116 children with non-infectious enteritis in the same period are set as the blank group,comparing the bias in serum PCT,CRP,Mb,CK-MB and cTnl levels in children within three types of enteritis.Results The levels of serum PCT,CRP and CK-MB in the observation group were higher than those in the control group and the blank group,and the difference was statistically significant(P<0.O1);children after being started with RVE for 3 days sees higher levels comparing with children on day 3,and the difference was statistically significant(P<0.01).Children with moderate to severe dehydration have higher levels of serum Mb,CK-MB and cTnI compared to children with no or mild dehydration..Among the five indicators,children with a greater increase in their total course of illness have also been prolonged.Conclusion Among the clinical test indicators of children with rotavirus enteritis,the combined detection of serum PCT,CRP,Mb,CK-MB and cTnI levels can be used to assist in the diagnosis of the disease,and also,to a certain extent,can indicate the progression and curation of the disease.