摘要
This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide derivatives.The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.
基金
We gratefully acknowledge the financial support from the Start-up Grant in Nanjing Tech University(Nos.39837118,39837146)
the National Natural Science Foundation of China(No.22001121).
