穿支动脉粥样硬化病患者早期神经功能恶化的研究进展

Advances in the Study of Early Neurological Deterioration in Patients with Branch Atheromatous Disease

穿支动脉粥样硬化病患者发病后容易发生早期神经功能恶化,导致患者功能预后不佳,给临床医师带来极大挑战。目前穿支动脉粥样硬化病患者早期神经功能恶化的发病机制尚未阐明,且在治疗方面缺乏有力的循证医学证据,一些观察性研究显示强化抗栓的策略可能是合理的。本文对穿支动脉粥样硬化病患者早期神经功能恶化的发病机制、风险预测及干预策略等方面的研究进行综述,以期提高临床医师的认识。

Patients with branch atheromatous disease(BAD)are prone to arteriosclerosis early neurological deterioration(END),which leads to poor functional prognosis and poses a great challenge to clinicians.At present,the pathogenesis of END in patients with BAD has not been elucidated,and there is a lack of strong evidence-based medical evidence in terms of treatment,with some observational studies suggesting that strategies of enhanced antithrombotic therapy may be justified.This paper reviews the research on the mechanism,risk prediction and intervention strategy of END in BAD patients in order to improve the awareness and attention of clinicians.