吉西他滨联合奥沙利铂治疗淋巴瘤的临床效果

Clinical Effect of Gemcitabine Combined with Oxaliplatin in the Treatment of Lymphoma

目的:分析吉西他滨联合奥沙利铂治疗淋巴瘤的临床效果。方法:选取2021年1月—2023年1月金乡县人民医院收治的淋巴瘤患者80例为观察对象,根据入院时间分为对照组与观察组,各40例。对照组给予吉西他滨治疗,观察组给予吉西他滨联合奥沙利铂治疗。比较两组治疗效果、癌症卡氏健康评分、癌因性疲乏评分、生活质量评分及毒副反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.043);治疗后,观察组癌症卡氏健康评分高于对照组,癌因性疲乏评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组生活能力、躯体症状、社会功能、心理健康评分高于对照组,差异有统计学意义(P<0.05);观察组毒副反应发生率低于对照组,差异有统计学意义(P=0.001)。结论:淋巴瘤患者实施吉西他滨联合奥沙利铂治疗能取得理想效果,可改善患者卡姓氏健康评分、癌因性疲乏评分,降低药物毒副反应,提升生活质量。

Objective:To analyze the clinical effect of gemcitabine combined with oxaliplatin in the treatment of lymphoma.Methods:A total of eighty patients with lymphoma admitted to Jinxiang County People's Hospital from January 2021 to January 2023 were selected as the observation objects,and were divided into control group and observation group according to the admission time,with forty cases in each group.The control group was treated with gemcitabine,and the observation group was treated with gemcitabine combined with oxaliplatin.The treatment effect,cancer Cartesier health score,cancer-related fatigue score,quality of life score and toxic side effects were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.043);After treatment,the cancer health score of the observation group was higher than that of the control group,and the cancer fatigue score was lower than that of the control group,with statistical significance(P<0.05);After treatment,the life ability,physical symptoms,social function and mental health scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05);The incidence of toxic and side effects in observation group was lower than that in control group,and the difference was statistically significant(P=0.001).Conclusion:Gemcitabine combined with oxaliplatin can achieve ideal results in lymphoma patients,which can improve patients'health score and cancer-related fatigue score,reduce drug toxicity and improve quality of life.