摘要
The azido group is found in large numbers of natural products,drugs,biochemicals and materials and to date,many elegant and useful methods for the synthesis of organic azides and their transformations have been documented.In this review,we provide a summary of the state of the art of radical azidation for the construction of C(sp^(3) )-N_(3) bonds.There is a specific emphasis on the synthetic reactions involving C(sp^(3))-H azidation,decar-boxylative azidation and difunctionalized azidation of olefins.This review will be useful to those working in this field and hopefully could inspire further development of radical azidation reactions.
基金
We thank the National Key R&D Program of China(No.2017YFA0700103)
the National Natural Science Foundation of China(Nos.21672213,21871258,21922112)
the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)
the Haixi Institute of CAS(No.CXZX-2017-P01)
the Innovative Research Teams Program II of Fujian Normal University in China(No.IRTL1703)for financial support.We thank Professor Kuiling Ding,Xue-Long Hou and Chaozhong Li from Shanghai Institute of Organic Chemistry,Armido Studer from University of Münster,Ning Jiao from Peking University,and Weiping Su from our institute for inspiring discussions on this review.
