创伤性脑损伤中“脑-肠轴”调节机制的研究进展

Progress in Research on the“Brain-Gut Axis”Regulation Mechanism in Traumatic Brain Injury

创伤性脑损伤(TBI)具有高发病率、高致残率、高致死率的特点。其治疗除处理颅脑损伤外,还需要关注损伤后出现的一系列继发性损伤和并发症。肠道微生物群和中枢神经系统之间的双向信号通路,称为脑-肠轴。研究证实,在TBI的继发性损伤中,存在具有双向调节作用的脑-肠轴,影响着TBI的进展与预后,但目前关于脑-肠轴在TBI后的功能和机制尚未完全明确。本综述将对TBI后脑-肠轴的双向调节机理研究进展进行总结分析。

Traumatic brain injury(TBI)is characterized by high morbidity,high disability rate,and high mortality.In addition to treating intracranial injuries,treatment of TBI also requires attention to a series of secondary injuries and complications that occur after injury.The bidirectional signaling pathway between the intestinal microbiome and the central nervous system is known as the brain-gut axis.Research has confirmed that in the secondary injury of TBI,there exists a brain-gut axis with bidirectional regulation affecting the progression and prognosis of TBI,but the functional and mechanistic aspects of the brain-gut axis after TBI have not yet been fully clarified.This review will summarize and analyze the progress in research on the bidirectional regulation mechanism of the brain-gut axis after TBI.